It was a German poet, who was also a doctor and scientist, that explained the
disease called botulism. Dr. Justinus Kerner of Wurttemberg, published the
first studies about the disease from 1817 to 1822. Dr. Kerner, a representative
of the romantic German poetic movement, had his poems turned into music by
Schumann. But in his first studies of the botulism, Dr. Kerner already imagined
that the toxin that caused such a serious disease, could be used to treat
diseases like muscular spasms. That great poet, great doctor, excellent scientist,
and amazing human being, always stood out in all of the areas he was involved.
But the medical poet could not glimpse that this toxin would one day be used
to treat people's appearance and to make them happier.
Dr. Justinus Kerner
In 1978, the toxin was applied in humans as treatment by Scott, and
surprisingly, it was so safe that it would be used in many other
medical indications, besides the aesthetics field. Jean Carrhuters
worked with Scott applying the toxin for strabismus treatment.
A strabismus patient treated by Carrhuters told him her wrinkles
got a lot better after the toxin was applied. Along with her husband,
Jean Carrhuters started to use the toxin for cosmetic proposes; it was the
beginning of a revolution that we have observed in the treatment of the wrinkles
and of the aging of the facial skin .
In a Botulism B epidemia in Switzerland, it was observed that the Botulinum
Toxin, besides the blocking action in the striated musculature, it also blocked
the neuro transmission of the autonomous nervous system. There were patients
with Botulism that presented sweating suppression that lasted up to 2 years
The first report of sweating suppression using the pharmacological Botulinum
Toxin was made in a study in 1995. At that time, a volunteer doctor injected
in himself 1 unit of Botulinum Toxin in the subcutaneous of the forearm. As
a result, the sweating of this region was decreased.
Then, in Europe, there were studies to block the sweating in volunteers without
Hyperhidrosis, and finally, in patients with axillary Hyperhidrosis. Therefore,
later in the USA, the toxin was applied in Hyperhidrosis of the hands.
Naturale Clinic’s head, Miguel Francischelli Neto MD PhD, presented the first scientific work in Brazil about the use of the Botulinum Toxin to control
the Hyperhidrosis. This scientific work was the fourth in the world. Many other
works , BY Prof. Francischelli, followed this one.
The use of toxins are part of the history of the medicine. It was the same
with the penicillin produced by a mushroom, and with the captopril, a drug
that is widely used for hypertension derived from the “jararaca” snake
poison. Many other toxins resulting from natural substances have been used
as well. The doses used for the treatment of the wrinkles are around 30 times
inferior to the ones that would cause larger complications or diseases. This
makes all the procedure very safe. The doctor, poet and scientist Kerner, would
be satisfied if he saw such dangerous toxin being tamed and used for the happiness
and the improvement of the people's quality of life
and Botulinum Toxin
do SNA em pacientes com botulismo B que apresentavam supressão
antebraço com supressão de sudorese.
de sudorese axilar em voluntários
de sudorese palmar em voluntários sadios.
11 pacientes com Hiper-hidrose axilar
e palmar . Aplicação
1 caso de Hiper-hidrose palmar.
4 casos de Hiper-hidrose palmar, aplicação intradérmica .
Supressão de 4 a 12 meses.
casos palmares e 1 axilar : Aplicação intradermica-
70 à 100 U
Congresso Brasileiro da SBACV- BH
24 casos axilares
:400 U - 4
casos retorno em 7 à 10
meses. Outros 20 sem Hiper-hidrose em